Public COVID-19 vaccination acceptance: A narrative review of correlated factors

Following the discovery of the first instances of COVID-19 in nations and the subsequent announcement of a “pandemic” by WHO, worldwide efforts to identify efficient methods to combat COVID-19 began. One of the most effective solutions is to carry out widespread vaccination against the virus. Despite this, some members of the community refuse to be vaccinated. The present paper reviews the potential causes and factors correlating with people's hesitation to receive COVID-19 vaccines. This article is a narrative review paper. We searched PubMed, Scopus, and Web of Science databases using COVID-19, Vaccine, Acceptance, and Hesitancy keywords. Qualitative content analysis was performed and associated predictors with public vaccination acceptance were identified. According to the study,  hesitation in receiving COVID-19 vaccines, regardless of the countries, is significant among females, lower ages, lower education level, doubt about efficacy, and concerns about the safety of the vaccines, history of not receiving vaccines, especially the influenza vaccine, distrust of regional or national health officials, low level of health literacy and lack of information, fear of side effects and other complications, doubt of pharmaceutical companies and fear of lobbying, presence of chronic underlying diseases and comorbidities, lower socioeconomic status and racial or religious minorities. According to the results, several factors can influence individuals' uncertainty about COVID-19 vaccines. Given the importance of vaccinating the majority of the community to achieve mass immunity, healthcare systems should consider the vaccine acceptance rate to be a vital and substantial factor.Keywords: COVID-19; Vaccination Refusal; Review

Droplet-based microfluidics in biomedical applications.

Droplet-based microfluidic systems have been employed to manipulate discrete fluid volumes with immiscible phases. Creating the fluid droplets at microscale has led to a paradigm shift in mixing, sorting, encapsulation, sensing, and designing high throughput devices for biomedical applications. Droplet microfluidics has opened many opportunities in microparticle synthesis, molecular detection, diagnostics, drug delivery, and cell biology. In the present review, we first introduce standard methods for droplet generation (i.e. passive and active methods) and discuss the latest examples of emulsification and particle synthesis approaches enabled by microfluidic platforms. Then, the applications of droplet-based microfluidics in different biomedical applications are detailed. Finally, a general overview of the latest trends along with the perspectives and future potentials in the field are provided